This journal was kept while Shippen was a student of medicine in London under Dr. Colin McKenzie and Dr. William Hunter. Notable people mentioned are Dennys De Berdt, Mark Akenside, George Whitefield, John Fothergill, David Garrick, and Thomas Penn.

This is a miscellaneous collection of deeds, indentures, and land surveys. Many names are represented, including James Claypole, Joseph Harrison, John Penn, Richard Penn, Thomas Penn, Zachariah Poulson, and William Shippen, Jr.

This volume contains approximately 175 letters written by Thomas Penn and Richard Penn on public business. A few are copies of letters by James Hamilton, a member of the Provincial Council and lieutenant governor of Pennsylvania, and by or to Abraham Taylor.

This volume is a daily record of purchases of books, paper, quills, ink, and other stationer's supplies. Customers include prominent Philadelphians.

Reports on conferences and treaties with the Indians and miscellaneous Indian affairs in Pennsylvania, with emphasis upon the French and Indian War. Correspondents include: John Armstrong Thomas Barton Edward Braddock Daniel Claus George Croghan James Hamilton James Logan Hugh Mercer Andrew Montour Robert Hunter Morris Robert Orme Ferdinand J. Paris Thomas Penn Horatio Sharpe Joseph Shippen William Shirley John Stanwix Robert Stobo William Trent Conrad Weiser

The first volume includes extracts from the journals of Conrad Weiser and Christian Frederick Post (1757), Charles Thomson's "An Enquiry into the causes of the alienation of the Delaware and Shawanese Indians from the British interest" (1759), and a printed version of Judge Bradford's "Statement of facts and observations respecting the penal laws" (1792). The second volume contains selected letters and documents in the Pennsylvania state records on Indian relations, including transcriptions of several treaties between the Province of Pennsylvania and the Delawares and other Indians (1755-1758); the French and Indian War; and Braddock's campaign. Some manuscripts are written by Deborah Norris Logan and Charles Thomson.